Rasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated

Stable Identifier
R-MMU-1169494
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated
In mouse B cells both Rasgrp1 and Rasgrp3 are activated by binding diacylglycerol at the plasma membrane (Johnson et al. 2007, Beaulieu et al. 2007) and being phosphorylated, thereby contributing to the activation of Ras in response to B cell receptor signaling (Coughlin et al. 2005).
Literature References
PubMed ID Title Journal Year
16301621 RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling

Coughlin, JJ, Stang, SL, Dower, NA, Stone, JC

J Immunol 2005
17523924 Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs

Johnson, JE, Goulding, RE, Ding, Z, Partovi, A, Anthony, KV, Beaulieu, N, Tazmini, G, Cornell, RB, Kay, RJ

Biochem J 2007
17567957 Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane

Beaulieu, N, Zahedi, B, Goulding, RE, Tazmini, G, Anthony, KV, Omeis, SL, de Jong, DR, Kay, RJ

Mol Biol Cell 2007
Participants
Input
Output
Orthologous Events
RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)
Authored
May, B  (2011-01-11)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2011-01-19)
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