Jak2 phosphorylates Stat1/Stat3

Stable Identifier
R-MMU-1169206
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
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Jak2 phosphorylates Stat1/Stat3
GH stimulated tyrosyl phosphorylation of Stats 1, 3, and 5 in CHO cells expressing GHR constructs that bind JAK2 but not in CHO cells expressing GHR constructs that do not bind JAK2 (Smit et al. 1996). STAT5 phosphorylation was greatly reduced in GHR mutants with the distal region of the cytoplasmic tail removed and by mutation of distal GHR tyrosine residues to phenylalanine but this had no effect on STAT1/STAT3 phosphorylation, suggesting that the latter interact with JAK2 directly.
Literature References
PubMed ID Title Journal Year
8732683 The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH

Smit, LS, Meyer, DJ, Billestrup, N, Norstedt, G, Schwartz, J, Carter-Su, C

Mol Endocrinol 1996
Participants
Input
Output
Catalyst Activity

non-membrane spanning protein tyrosine kinase activity of Growth hormone:Activated growth hormone receptor-p-Jak2 dimer:Stat1/Stat3 [plasma membrane]

Physical Entity
Growth hormone:Activated growth hormone receptor-p-Jak2 dimer:Stat1/Stat3 [plasma membrane] (Mus musculus)
Activity
non-membrane spanning protein tyrosine kinase activity (GO:0004715)
Orthologous Events
JAK2 phosphorylates STAT1/STAT3 (Homo sapiens)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-13)
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