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Il6ra [extracellular region]
Stable Identifier
R-MMU-1067661
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
IL6R-2, P22272
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-6 family signaling (Mus musculus)
Interleukin-6 signaling (Mus musculus)
Assembly of hexameric IL-6 receptor (Mus musculus)
IL6 receptor hexamer:JAKs [plasma membrane] (Mus musculus)
IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6 binds IL6R-2 (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6:IL6R-2 binds IL6ST-2 (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6ST is tyrosine phosphorylated (Mus musculus)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
JAK activation (Mus musculus)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
IL6 receptor hexamer:JAKs [plasma membrane] (Mus musculus)
IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
PTPN11 binds CBL (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
PTPN11 binds p-Y759-IL6ST (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
PTPN11 is phosphorylated (Mus musculus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Phosphorylated STATs are released (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
SOCS3 binds IL6ST (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Serine phosphorylation of STATs (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
MAPK1 (ERK2) activation (Mus musculus)
MAP2K2 binds MAPK1 (Mus musculus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
MAPK3 (ERK1) activation (Mus musculus)
MAP2K1 binds MAPK3 (Mus musculus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
IL6:IL6R-2 [extracellular region] (Mus musculus)
Il6ra [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P22272 Il6ra
Gene Names
Il6ra, Il6r
Chain
signal peptide:1-19, chain:20-460, chain:20-354
Reference Genes
BioGPS Gene:16194 Il6ra
CTD Gene:16194 Il6ra
ENSEMBL:ENSMUSG00000027947.12 Il6ra
KEGG Gene (Mus musculus):16194 Il6ra
Monarch:16194 Il6ra
NCBI Gene:16194 Il6ra
UCSC:P22272 Il6ra
Reference Transcript
RefSeq:NM_010559.3 Il6ra
Other Identifiers
104268_at
10499655
1422270_a_at
1452416_at
16194
17407138
4398883
4609513
4729779
4754831
4762666
4800010
4904356
4905083
4920931
5011385
5243845
5265017
5281502
5390403
5588185
A_51_P415855
A_51_P415863
A_55_P2068892
GE36473
GO:0002376
GO:0004896
GO:0004897
GO:0004915
GO:0004921
GO:0005138
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005896
GO:0007155
GO:0008284
GO:0009897
GO:0010573
GO:0016020
GO:0016324
GO:0019221
GO:0019899
GO:0019970
GO:0019981
GO:0023052
GO:0030154
GO:0031018
GO:0032722
GO:0032755
GO:0032809
GO:0032966
GO:0034097
GO:0036211
GO:0038154
GO:0042060
GO:0042531
GO:0042803
GO:0043235
GO:0043410
GO:0048589
GO:0048661
GO:0048856
GO:0050731
GO:0060089
GO:0070102
GO:0070110
GO:0070119
GO:0070120
GO:0072126
GO:0072540
GO:1901731
ILMN_1225590
ILMN_1255743
ILMN_2706430
mMC008481
x51975_s_at
Participates
as an input of
IL6 binds IL6R-2 (Mus musculus)
as a component of
IL6:IL6R-2 [extracellular region] (Mus musculus)
Other forms of this molecule
Il6ra [plasma membrane]
Il6ra [plasma membrane]
Inferred From
IL6R-2 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_034689.2
Ensembl
ENSMUSG00000027947
,
ENSMUSP00000029559
,
ENSMUST00000029559
PRO
P22272
MGI
105304
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