Reactome | Il6ra [extracellular region]

Il6ra [extracellular region]

Stable Identifier

R-MMU-1067661

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

IL6R-2, P22272

Locations in the PathwayBrowser

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Cell-Cell communication (Mus musculus)

- Cell junction organization (Mus musculus)
  - Cell-cell junction organization (Mus musculus)
    - Adherens junctions interactions (Mus musculus)
      - Activation of STAT3 by cadherin engagement (Mus musculus)
        
        Assembly of hexameric IL-6 receptor (Mus musculus)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6 binds IL6R-2 (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:IL6R-2:IL6ST-2 [extracellular region] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6ST is tyrosine phosphorylated (Mus musculus)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        JAK activation (Mus musculus)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST binds STAT3 (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylation of STAT3 by IL6 receptor (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        p-Y705-STAT3 dissociates from IL6 receptor (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-6 family signaling (Mus musculus)
      - Interleukin-6 signaling (Mus musculus)
        
        Assembly of hexameric IL-6 receptor (Mus musculus)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6 binds IL6R-2 (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:IL6R-2 binds IL6ST-2 (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:IL6R-2:IL6ST-2 [extracellular region] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:IL6R-2:IL6ST-2 [extracellular region] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6ST is tyrosine phosphorylated (Mus musculus)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        JAK activation (Mus musculus)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        PTPN11 binds CBL (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        PTPN11 binds p-Y759-IL6ST (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        PTPN11 is phosphorylated (Mus musculus)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Phosphorylated STATs are released (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        SOCS3 binds IL6ST (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Serine phosphorylation of STATs (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF-independent MAPK1/3 activation (Mus musculus)
      - MAPK1 (ERK2) activation (Mus musculus)
        
        MAP2K2 binds MAPK1 (Mus musculus)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)
      - MAPK3 (ERK1) activation (Mus musculus)
        
        MAP2K1 binds MAPK3 (Mus musculus)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6R-2 [extracellular region] (Mus musculus)
        
        Il6ra [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P22272 Il6ra

Gene Names

Il6ra, Il6r

Chain

signal peptide:1-19, chain:20-460, chain:20-354

Reference Genes

BioGPS Gene:16194 Il6ra

CTD Gene:16194 Il6ra

KEGG:mmu:16194 Il6ra

Monarch:16194 Il6ra

NCBI Gene:16194 Il6ra

UCSC:P22272 Il6ra

Reference Transcript

RefSeq:NM_010559.3 Il6ra

Other Identifiers

104268_at

10499655

1422270_a_at

1452416_at

16194

17407138

4372977

4398883

4451876

4534292

4609513

4710316

4729779

4754831

4762666

4800010

4904356

4905083

4920931

5011385

5100751

5243845

5265017

5281502

5355589

5390403

5588185

95367_at

A_51_P415855

A_51_P415863

A_55_P2068892

GE36473

GO:0004896

GO:0004897

GO:0004915

GO:0004921

GO:0005138

GO:0005515

GO:0005576

GO:0005886

GO:0005896

GO:0008284

GO:0009897

GO:0010573

GO:0016020

GO:0016324

GO:0019221

GO:0019899

GO:0019970

GO:0019981

GO:0031018

GO:0032502

GO:0032722

GO:0032755

GO:0034097

GO:0038154

GO:0042803

GO:0043235

GO:0048661

GO:0048856

GO:0070102

GO:0070110

GO:0070119

GO:0070120

GO:0072126

GO:0072540

GO:0097696

ILMN_1216057

ILMN_1225590

ILMN_1255743

ILMN_2706430

mMC008481

x51975_s_at

Participates

as an input of

IL6 binds IL6R-2 (Mus musculus)

as a component of

IL6:IL6R-2 [extracellular region] (Mus musculus)

Other forms of this molecule

Il6ra [plasma membrane]

Inferred From

IL6R-2 [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_034689.2

ENSEMBL

ENSMUSG00000027947, ENSMUSP00000029559, ENSMUST00000029559

PRO

P22272

GlyGen

P22272

MGI

105304

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