Reactome | IL6R-2 [extracellular region]

IL6R-2 [extracellular region]

Stable Identifier

R-HSA-1067661

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

sIL6R, Interleukin-6 receptor subunit alpha short soluble form, IL6RA_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-6 family signaling (Homo sapiens)
      - Interleukin-6 signaling (Homo sapiens)
        
        Assembly of hexameric IL-6 receptor (Homo sapiens)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6 binds IL6R-2 (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6ST is tyrosine phosphorylated (Homo sapiens)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        JAK activation (Homo sapiens)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        PTPN11 binds CBL (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        PTPN11 binds p-Y759-IL6ST (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        PTPN11 is phosphorylated (Homo sapiens)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Phosphorylated STATs are released (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        SOCS3 binds IL6ST (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Serine phosphorylation of STATs (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF-independent MAPK1/3 activation (Homo sapiens)
      - MAPK1 (ERK2) activation (Homo sapiens)
        
        MAP2K2 binds MAPK1 (Homo sapiens)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
      - MAPK3 (ERK1) activation (Homo sapiens)
        
        MAP2K1 binds MAPK3 (Homo sapiens)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08887-2 IL6R

Gene Names

IL6R

Participates

as an input of

IL6 binds IL6R-2 (Homo sapiens)

as a component of

IL6:IL6R-2 [extracellular region] (Homo sapiens)

Inferred To

IL6R [extracellular region] (Bos taurus)

Il6ra [extracellular region] (Mus musculus)

Ghost homologue of IL6R-2 [extracellular region] (Sus scrofa)

Ghost homologue of IL6R-2 [extracellular region] (Xenopus tropicalis)

IL6R-2 [extracellular region] (Canis familiaris)

IL6R-2 [extracellular region] (Gallus gallus)

Il6r [extracellular region] (Rattus norvegicus)

cntfr [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_001193795.1, NP_852004.1, NP_000556.1

Guide to Pharmacology - Targets

1708

ENSEMBL

ENST00000344086, ENSG00000160712, ENSP00000340589, ENSP00000357470, ENST00000368485

OpenTargets

ENSG00000160712

GeneCards

IL6R

HPA

ENSG00000160712-IL6R

PRO

P08887

Pharos - Targets

P08887

GlyGen

P08887

Orphanet

IL6R

PDB

8QY5, 8QY6, 8IOW, 8D82, 1P9M, 2ARW, 7DC8, 5FUC, 1N26

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05231 IL6	3	IL6 [extracellular region] (R-HSA-447100) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044)	0.823	7
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.619	7
UniProt:Q2HRC7 VIL6			0.591	3
UniProt:Q96EQ0 SGTB			0.556	3

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