Reactome | IL6R-2 [extracellular region]

IL6R-2 [extracellular region]

Stable Identifier

R-HSA-1067661

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

sIL6R, Interleukin-6 receptor subunit alpha short soluble form, IL6RA_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-6 family signaling (Homo sapiens)
      - Interleukin-6 signaling (Homo sapiens)
        
        Assembly of hexameric IL-6 receptor (Homo sapiens)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6 binds IL6R-2 (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6ST is tyrosine phosphorylated (Homo sapiens)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        JAK activation (Homo sapiens)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        PTPN11 binds CBL (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        PTPN11 binds p-Y759-IL6ST (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        PTPN11 is phosphorylated (Homo sapiens)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Phosphorylated STATs are released (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        SOCS3 binds IL6ST (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Serine phosphorylation of STATs (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF-independent MAPK1/3 activation (Homo sapiens)
      - MAPK1 (ERK2) activation (Homo sapiens)
        
        MAP2K2 binds MAPK1 (Homo sapiens)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)
      - MAPK3 (ERK1) activation (Homo sapiens)
        
        MAP2K1 binds MAPK3 (Homo sapiens)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
        
        IL6:IL6R-2 [extracellular region] (Homo sapiens)
        
        IL6R-2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08887-2 IL6R

Gene Names

IL6R

Other Identifiers

0001400113

0006180278

11736509_x_at

11736510_a_at

11741958_a_at

11741959_x_at

160032_at

16671457

205945_at

217489_s_at

226333_at

2360258

2360259

2360260

2360268

2360269

2360271

2360272

2360273

2360274

2360275

2360277

2360281

2360282

2360286

2360287

2360288

2360289

2360290

2360291

2360292

3570

48565_at

7905789

985_s_at

A_14_P131110

A_21_P0000171

A_24_P379413

A_33_P3288844

GE79044

GE85597

GO:0002376

GO:0002384

GO:0002548

GO:0002690

GO:0003674

GO:0004896

GO:0004897

GO:0004915

GO:0004921

GO:0005138

GO:0005515

GO:0005575

GO:0005576

GO:0005886

GO:0005896

GO:0006464

GO:0006950

GO:0006953

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009897

GO:0010536

GO:0010573

GO:0016020

GO:0016021

GO:0016324

GO:0019221

GO:0019899

GO:0019955

GO:0019970

GO:0019981

GO:0030154

GO:0031018

GO:0032722

GO:0032755

GO:0032991

GO:0034097

GO:0038154

GO:0040011

GO:0042531

GO:0042803

GO:0043235

GO:0045669

GO:0048661

GO:0048856

GO:0048870

GO:0050731

GO:0050829

GO:0070102

GO:0070110

GO:0070119

GO:0070120

GO:0072126

GO:0072540

GO:0097191

Hs.17998.0.S1_3p_at

Hs.193400.1.S1_3p_a_at

ILMN_1696394

ILMN_1754753

M20566_at

PH_hs_0011409

TC01001276.hg

X58298_s_at

g4504672_3p_at

Participant Of

input

IL6 binds IL6R-2

hasComponent

IL6:IL6R-2 [extracellular region]

Inferred To

IL6R [extracellular region] (Bos taurus)

IL6R [extracellular region] (Canis familiaris)

Il6ra [extracellular region] (Mus musculus)

il11ra [extracellular region] (Danio rerio)

IL6R-2 [extracellular region] (Gallus gallus)

IL6R-2 [extracellular region] (Xenopus tropicalis)

Il6r [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001193795.1, NP_000556.1, NP_852004.1

OpenTargets

ENSG00000160712

HPA

ENSG00000160712-IL6R

GeneCards

P08887

Ensembl

ENST00000344086, ENSP00000340589, ENSG00000160712, ENSP00000357470, ENST00000368485

PRO

P08887

PDB

1P9M, 1N26, 1N2Q, 5FUC, 2ARW

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05231 IL6	3	IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044) IL6 [extracellular region] (R-HSA-447100)	0.823	7
UniProt:Q92673 SORL1	2	SORL1 [Golgi membrane] (R-HSA-8871510) SORL1 [endosome membrane] (R-HSA-8871475)	0.619	7
UniProt:Q2HRC7 VIL6			0.591	3
UniProt:Q96EQ0 SGTB			0.556	3

Cite Us!