IL4 signaling produces phosphorylated STAT6 dimers and T cell receptor signaling produces dephosphorylated NFATC2 (NFAT1), both of which bind to the GATA3 gene and activate its expression (inferred from mouse homologs in Scheinman and Avni 2009, Wei et al. 2010, Onodera et al. 2010). Phosphorylated STAT6 dimers recruit MLL1 complexes to positively regulate transcription (inferred from mouse homologs in Onodera et al. 2010). Activation of NOTCH1,2 signaling by JAGGED1 or JAGGED2 located on antigen presenting cells results in generation of NICD1,2, the intracellular cleavage product of NOTCH1,2, which binds to RBPJ at the upstream promoter of the GATA3 gene and recruits coactivators to enhance its transcription (inferred from mouse homologs in Amsen et al. 2004, 2007, Fang et al. 2007).