Reactome | AADAT transaminates 3HKYN to xanthurenate

AADAT transaminates 3HKYN to xanthurenate

Stable Identifier

R-HSA-9972889

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

3-hydroxy-L-kynurenine + glyoxylate => xanthurenate + glycine + H2O

ReviewStatus

5/5

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AADAT transaminates 3HKYN to xanthurenate

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Kynurenine/alpha-aminoadipate aminotransferase (AADAT, KAT II) dimer transaminates 3-hydroxykynurenine (3HKYN) to xanthurenate, simultaneosly producing glycine (Gly) from glyoxylate. This reaction increases with age and B6 deficiency (Han et al., 2008; Sathyasaikumar et al., 2017). The cytosolic localization of human AADAT is inferred from work in rats (Rzeski et al., 2005).

Literature References

PubMed ID	Title	Journal	Year
15880762	Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons Rzeski, W, Kocki, T, Dybel, A, Wejksza, K, Zdzisińska, B, Kandefer-Szerszeń, M, Turski, WA, Okuno, E, Albrecht, J	J Neurosci Res	2005
18620547	Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II Han, Q, Cai, T, Tagle, DA, Robinson, H, Li, J	Biosci Rep	2008
29031603	Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects Sathyasaikumar, KV, Tararina, M, Wu, HQ, Neale, SA, Weisz, F, Salt, TE, Schwarcz, R	Neuroscience	2017