GLYAT transfers ISB to glycine

Stable Identifier
R-HSA-9971621
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)
ReviewStatus
5/5
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GLYAT transfers ISB to glycine
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Glycine N-acyltransferase (GLYAT) transfers the isobutyryl moiety from ISB-CoA to glycinate, forming isobutyrylglycinate (Gregersen et al., 1986).
Literature References
PubMed ID Title Journal Year
3707752 Acyl-CoA: glycine N-acyltransferase: in vitro studies on the glycine conjugation of straight- and branched-chained acyl-CoA esters in human liver

Gregersen, N, Kølvraa, S, Mortensen, PB

Biochem Med Metab Biol 1986
Participants
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Output
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as an event of
Catalyst Activity

glycine N-acyltransferase activity of GLYAT [mitochondrial matrix]

Physical Entity
GLYAT [mitochondrial matrix] (Homo sapiens)
Activity
glycine N-acyltransferase activity (GO:0047961)
Orthologous Events
GLYAT transfers ISB to glycine (Bos taurus)
GLYAT transfers ISB to glycine (Caenorhabditis elegans)
GLYAT transfers ISB to glycine (Canis familiaris)
GLYAT transfers ISB to glycine (Gallus gallus)
GLYAT transfers ISB to glycine (Mus musculus)
GLYAT transfers ISB to glycine (Rattus norvegicus)
GLYAT transfers ISB to glycine (Sus scrofa)
GLYAT transfers ISB to glycine (Xenopus tropicalis)
Cross References
RHEA
Authored
Stephan, R  (2025-11-08)
Reviewed
D'Eustachio, P  (2026-02-10)
Created
Stephan, R  (2025-11-08)
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