Reactome | SLC25A20 exports excess acyl-CAR

SLC25A20 exports excess acyl-CAR

Stable Identifier

R-HSA-9971094

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20, CACT) exports excess acylcarnitines out of mitochondria. This reversed process is possible because the transport mechanism is completely dependent on the concentration gradient of substrates (Schaefer et al., 1997; Ventura et al., 1998).

Literature References

PubMed ID	Title	Journal	Year
9048718	Characterisation of carnitine palmitoyltransferases in patients with a carnitine palmitoyltransferase deficiency: implications for diagnosis and therapy Schaefer, J, Jackson, S, Taroni, F, Swift, P, Turnbull, DM	J Neurol Neurosurg Psychiatry	1997
9654057	Carnitine palmitoyltransferase II specificity towards beta-oxidation intermediates--evidence for a reverse carnitine cycle in mitochondria Ventura, FV, Ijlst, L, Ruiter, J, Ofman, R, Costa, CG, Jakobs, C, Duran, M, Tavares de Almeida, I, Bieber, LL, Wanders, RJ	Eur J Biochem	1998