XRN2 degrades downstream RNA fragment, promoting transcription termination

Stable Identifier
R-HSA-9971054
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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XRN2 degrades downstream RNA fragment, promoting transcription termination
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XRN2 (5'‑3' exoribonuclease 2) is the enzyme involved in degradation of the 3' cleavage fragment, which helps to terminate transcription by RNA Polymerase II (RNA Pol II) in a CPSF3 (also known as CPSF73)‑ and PP1‑dependent manner (West et al. 2004; Eaton et al. 2018; Eaton et al. 2020).
Literature References
PubMed ID Title Journal Year
29432121 Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

Eaton, JD, Davidson, L, Bauer, DLV, Natsume, T, Kanemaki, MT, West, S

Genes Dev 2018
15565158 Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites

West, S, Gromak, N, Proudfoot, NJ

Nature 2004
31805520 A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes

Eaton, JD, Francis, L, Davidson, L, West, S

Genes Dev 2020
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Catalyst Activity

5'-3' RNA exonuclease activity of XRN2 [nucleoplasm]

Physical Entity
XRN2 [nucleoplasm] (Homo sapiens)
Activity
5'-3' RNA exonuclease activity (GO:0004534)
Authored
Ahluwalia, R  (2025-10-01)
Reviewed
Ahluwalia, R  (2025-11-10)
Created
Orlic-Milacic, M  (2025-11-04)
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