CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)

Stable Identifier
R-HSA-9970428
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)
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Upon completion of polyadenylation, the cleavage and polyadenylation complex dissociates from target pre-mRNA, which enables it to catalyze another round of cleavage and polyadenylation (Zarkower and Wickens 1989: nuclear extracts of human cervical carcinoma cell line HeLa were used). This is expected to occur irrespective of the polyadenylation site (PAS) used in the pre-mRNA, including distal 3' UTR PASs.
Literature References
PubMed ID Title Journal Year
2438129 Formation of mRNA 3' termini: stability and dissociation of a complex involving the AAUAAA sequence

Zarkower, D, Wickens, M

EMBO J 1987
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Orthologous Events
CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Bos taurus)
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CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Rattus norvegicus)
Authored
Ahluwalia, R  (2025-10-01)
Reviewed
Ahluwalia, R  (2025-11-10)
Created
Orlic-Milacic, M  (2025-10-29)
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