AOC1 dimer oxidizes MeHist

Stable Identifier
R-HSA-9970023
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
N(tau)-methylhistamine + O2 + H2O => 1-methylimidazole-4-acetaldehyde + H2O2 + NH4(+)
ReviewStatus
5/5
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AOC1 dimer oxidizes MeHist
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Diamine oxidase [copper-containing] (AOC1) dimer catalyzes the oxidation of N(tau)-methylhistamine, consuming one molecule of water and oxygen, and producing 1-methylimidazole-4-acetaldehyde and one molecule each of H2O2 and NH4+ (Elmore et al., 2002).
Literature References
PubMed ID Title Journal Year
12072962 Human kidney diamine oxidase: heterologous expression, purification, and characterization

Elmore, BO, Bollinger, JA, Dooley, DM

J Biol Inorg Chem 2002
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as an event of
Catalyst Activity

histamine oxidase activity of AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane]

Physical Entity
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Homo sapiens)
Activity
histamine oxidase activity (GO:0052598)
Orthologous Events
AOC1 dimer oxidizes MeHist (Bos taurus)
AOC1 dimer oxidizes MeHist (Danio rerio)
AOC1 dimer oxidizes MeHist (Gallus gallus)
AOC1 dimer oxidizes MeHist (Mus musculus)
AOC1 dimer oxidizes MeHist (Rattus norvegicus)
AOC1 dimer oxidizes MeHist (Xenopus tropicalis)
Cross References
RHEA
Authored
Stephan, R  (2025-10-27)
Reviewed
D'Eustachio, P  (2026-02-10)
Created
Stephan, R  (2025-10-27)
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