Reactome | RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide

RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide

Stable Identifier

R-HSA-9948291

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide

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The ASCC2 subunit (Narita et al. 2022) of the Activating Signal Co-integrator 1 complex (ASCC or ASC-1 complex, ASCC2:ASCC3:TRIP4, homolog of the ribosome quality control trigger complex RQT complex in yeast) binds K63-linked polyubiquitin conjugated to the RPS20 subunit of the 40S ribosomal subunit (Hashimoto et al. 2020, Juszkiewicz et al. 2020, Narita et al. 2022, and inferred from yeast homologs in Matsuo et al. 2023). RPS10 ubiquitination is required for activity of the ASC-1 complex (Juszkiewicz and Hegde 2017, Matsuo et al. 2020). In yeast, RQT4 (homolog of TRIP4) also binds K63-linked polyubiquitin (Matsuo et al. 2023).

Literature References

PubMed ID	Title	Journal	Year
32099016	Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells Hashimoto, S, Sugiyama, T, Yamazaki, R, Nobuta, R, Inada, T	Sci Rep	2020
28065601	Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination Juszkiewicz, S, Hegde, RS	Mol Cell	2017
36302773	A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation Narita, M, Denk, T, Matsuo, Y, Sugiyama, T, Kikuguchi, C, Ito, S, Sato, N, Suzuki, T, Hashimoto, S, Machová, I, Tesina, P, Beckmann, R, Inada, T	Nat Commun	2022
32579943	The ASC-1 Complex Disassembles Collided Ribosomes Juszkiewicz, S, Speldewinde, SH, Wan, L, Svejstrup, JQ, Hegde, RS	Mol Cell	2020