Import of DENV RNA from exosomes

Stable Identifier
R-HSA-9947465
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol, extracellular exosome
ReviewStatus
5/5
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Import of DENV RNA from exosomes
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DENV genomic RNA can be transferred by extracellular vesicles (EVs) from mosquito to mammalian and human cells (Vora et al., 2018), and DENV subgenomic RNA can be transferred by EVs from BHK cells to various cell types (Ishikawa et al., 2024; reviewed in Athira et al., 2024). Import of EVs containing DENV NGC subgenomic replicon RNA into recipient cells was found to be primarily through macropinocytosis in HeLa cells, and might involve interaction with CD33 (in HeLa cells), or involve interaction with Hepatitis A virus cellular receptor 1 (HAVCR1, TIM1) and T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4, TIM4) in K562 cells (Ishikawa et al., 2024). It is unknown how many cells take up RNA-carrying EVs during Dengue infection and how many cells become virus-producing through this process.
Literature References
PubMed ID Title Journal Year
39225901 Dual Role of Extracellular Vesicles as Orchestrators of Emerging and Reemerging Virus Infections

Athira, AP, Sreekanth, S, Chandran, A, Lahon, A

Cell Biochem Biophys 2025
29946031 Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb

Vora, A, Zhou, W, Londono-Renteria, B, Woodson, M, Sherman, MB, Colpitts, TM, Neelakanta, G, Sultana, H

Proc Natl Acad Sci U S A 2018
38675867 Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles

Ishikawa, T, Narita, K, Matsuyama, K, Masuda, M

Viruses 2024
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
macropinocytosis (0044351)
This event is regulated
Positively by
Regulator
TIMD4 [plasma membrane] (Homo sapiens)
Regulator
HAVCR1 [plasma membrane] (Homo sapiens)
Regulator
CD33 [plasma membrane] (Homo sapiens)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2025-05-06)
Reviewed
Mansur, DS  (2025-10-29)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2025-05-06)
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