NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol

Stable Identifier
R-HSA-9945822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
Synonyms
4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH
ReviewStatus
5/5
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NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol
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NSDHL (Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating), in the endoplasmic reticulum membrane, decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Liu et al. 1999).
Literature References
PubMed ID Title Journal Year
10369263 The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase

Liu, XY, Dangel, AW, Kelley, RI, Zhao, W, Denny, P, Botcherby, M, Cattanach, B, Peters, J, Hunsicker, PR, Mallon, AM, Strivens, MA, Bate, R, Miller, W, Rhodes, M, Brown, SD, Herman, GE

Nat Genet 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]

Physical Entity
NSDHL [endoplasmic reticulum membrane] (Homo sapiens)
Activity
3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity (GO:0000252)
Orthologous Events
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Bos taurus)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Canis familiaris)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Danio rerio)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Dictyostelium discoideum)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Gallus gallus)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Mus musculus)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Rattus norvegicus)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Saccharomyces cerevisiae)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Schizosaccharomyces pombe)
NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol (Sus scrofa)
Cross References
RHEA
Authored
D'Eustachio, P  (2025-04-18)
Reviewed
Hill, DP  (2025-05-30)
Created
D'Eustachio, P  (2025-04-18)
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