CHD8:CTNNB1 represses AXIN2 expression

Stable Identifier
R-HSA-9944652
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
3/5
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CHD8:CTNNB1 represses AXIN2 expression
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AXIN2 expression is upregulated in CHD8 knockdown HCT116 cells, consistent for a role of CHD8:CTNNB1 in the negative regulation of this WNT target gene (Thompson et al, 2008; Sakamoto et al, 2000; Kobayashi et al, 2002).
Literature References
PubMed ID Title Journal Year
18378692 CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes

Thompson, BA, Tremblay, V, Lin, G, Bochar, DA

Mol. Cell. Biol. 2008
10921920 A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation

Sakamoto, I, Kishida, S, Fukui, A, Kishida, M, Yamamoto, H, Hino, S, Michiue, T, Takada, S, Asashima, M, Kikuchi, A

J. Biol. Chem. 2000
11744694 Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway

Kobayashi, M, Kishida, S, Fukui, A, Michiue, T, Miyamoto, Y, Okamoto, T, Yoneda, Y, Asashima, M, Kikuchi, A

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CTNNB1:CHD8 [nucleoplasm] (Homo sapiens)
Active Unit
CHD8 [nucleoplasm]
Authored
Rothfels, K  (2025-02-07)
Created
Rothfels, K  (2025-04-06)
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