CHD8:CTNNB1 represses NKD2 expression

Stable Identifier
R-HSA-9944646
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
3/5
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CHD8:CTNNB1 represses NKD2 expression
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NKD2 expression is upregulated in CHD8 knockdown HCT116 cells, consistent for a role of CHD8:CTNNB1 in the negative regulation of this WNT target gene (Thompson et al, 2008; Sakamoto et al, 2000; Kobayashi et al, 2002). Based on similarity to proteins in Drosophila, NKD2 is thought to be a cell autonomous negative regulator of canonical WNT signaling (Yan et al, 2001; Wharton et al, 2001).
Literature References
PubMed ID Title Journal Year
18378692 CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes

Thompson, BA, Tremblay, V, Lin, G, Bochar, DA

Mol. Cell. Biol. 2008
10921920 A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation

Sakamoto, I, Kishida, S, Fukui, A, Kishida, M, Yamamoto, H, Hino, S, Michiue, T, Takada, S, Asashima, M, Kikuchi, A

J. Biol. Chem. 2000
11356022 Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling

Wharton, KA, Zimmermann, G, Rousset, R, Scott, MP

Dev Biol 2001
11744694 Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway

Kobayashi, M, Kishida, S, Fukui, A, Michiue, T, Miyamoto, Y, Okamoto, T, Yoneda, Y, Asashima, M, Kikuchi, A

J. Biol. Chem. 2002
11274398 Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

Yan, D, Wallingford, JB, Sun, TQ, Nelson, AM, Sakanaka, C, Reinhard, C, Harland, RM, Fantl, WJ, Williams, LT

Proc Natl Acad Sci U S A 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CTNNB1:CHD8 [nucleoplasm] (Homo sapiens)
Active Unit
CHD8 [nucleoplasm]
Authored
Rothfels, K  (2025-02-07)
Created
Rothfels, K  (2025-04-06)
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