NuRD deacetylates nucleosomes

Stable Identifier
R-HSA-9944092
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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NuRD deacetylates nucleosomes
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This reaction shows a generic representation of the histone deacetylation activity of the NuRD complex on a non-specific acetylated chromatin template. The NuRD complex is recruited to specific regions in the genome by virtue of the DNA- and histone-binding properties of its components, as well as through protein-protein interactions with sequence-specific transcription factors, some of which are illustrated in this pathway (reviewed in Asmamaw et al, 2024; Alendar and Berns, 2021). NuRD binds to a di-nucleosome substrate and interacts with adjacent acetylated nucleosomes (Millard et al, 2013). Histone deacetylase activity is provided by the HDAC1 and/or HDAC2 components of the complex. (Xue et al, 1998; reviewed in Torchy et al, 2015).
Literature References
PubMed ID Title Journal Year
23791785 Class I HDACs share a common mechanism of regulation by inositol phosphates

Millard, CJ, Watson, PJ, Celardo, I, Gordiyenko, Y, Cowley, SM, Robinson, CV, Fairall, L, Schwabe, JW

Mol Cell 2013
34725129 Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease

Alendar, A, Berns, A

Genes Dev 2021
38971208 Histone deacetylase complexes: Structure, regulation and function

Asmamaw, MD, He, A, Zhang, LR, Liu, HM, Gao, Y

Biochim Biophys Acta Rev Cancer 2024
9885572 NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities

Xue, Y, Wong, J, Moreno, GT, Young, MK, Côté, J, Wang, W

Mol. Cell 1998
25796366 Structure and function insights into the NuRD chromatin remodeling complex

Torchy, MP, Hamiche, A, Klaholz, BP

Cell Mol Life Sci 2015
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Catalyst Activity

histone deacetylase activity of NuRD [nucleoplasm]

Physical Entity
NuRD [nucleoplasm] (Homo sapiens)
Activity
histone deacetylase activity (GO:0004407)
Cross References
RHEA
Authored
Rothfels, K  (2025-02-07)
Created
Rothfels, K  (2025-04-02)
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