Reactome | NEK11 [nucleoplasm]

NEK11 [nucleoplasm]

Stable Identifier

R-HSA-9943655

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Serine/threonine-protein kinase Nek11 ecNumber evidence="6 8"2.7.11.1, NEK11_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P51955 NEK2

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Independent G1/S DNA Damage Checkpoint (Homo sapiens)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
        
        CHEK1 phosphorylates NEK11 (Homo sapiens)
        
        NEK11 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NG66 NEK11

Gene Names

NEK11

Chain

chain:1-645

Reference Genes

BioGPS Gene:79858 NEK11

COSMIC - genes:NEK11 NEK11

CTD Gene:79858 NEK11

dbSNP Gene:79858 NEK11

ENSEMBL:ENSG00000114670 NEK11

HGNC:18593 NEK11

KEGG:hsa:79858 NEK11

Monarch:79858 NEK11

NCBI Gene:79858 NEK11

OMIM:609779 NEK11

UCSC:Q8NG66 NEK11

Reference Transcript

Other Identifiers

11735886_a_at

11735887_at

11737916_a_at

11745473_a_at

11750791_a_at

1554380_PM_at

1554380_at

1555082_3p_a_at

1555082_PM_a_at

1555082_a_at

16945625

219542_PM_at

219542_at

2642403

2642442

2642443

2642444

2642445

2642446

2642447

2642448

2642449

2642453

2642456

2642457

2642458

2642459

2642460

2642462

2642463

2642464

2642465

2642467

2642468

2642469

2642472

2642473

2642475

2642478

2642479

2642480

2642484

2642486

2642488

2642489

2642490

2642491

2642506

2642512

2642524

2642544

45650_at

79858

8082643

81715_at

A_14_P125088

A_14_P133448

A_23_P155301

A_23_P211973

GE62322

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0006468

GO:0016301

GO:0016740

GO:0031573

GO:0035556

GO:0046872

GO:0106310

GO:0140096

GO:1901990

HMNXSV003011290

HMNXSV003016961

Hs2.159146.2.S1_3p_at

Hs2.159146.3.S1_3p_at

Hs2.159146.3.S1_3p_s_at

ILMN_1788149

ILMN_1813645

ILMN_2365223

PH_hs_0009663

TC03000708.hg

g13376174_3p_at

Participates

as an input of

CHEK1 phosphorylates NEK11 (Homo sapiens)

Other forms of this molecule

p-S273-NEK11 [nucleoplasm]

Inferred To

nek11 [nucleoplasm] (Danio rerio)

NEK11 [nucleoplasm] (Bos taurus)

NEK11 [nucleoplasm] (Dictyostelium discoideum)

NEK11 [nucleoplasm] (Mus musculus)

NEK11 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_047304927.1, XP_047304928.1, NP_001308150.1, NP_001308152.1, NP_001308153.1, NP_001308151.1, NP_001139475.1, NP_001308149.1, NP_665917.1, NP_001339952.1, NP_001339957.1, NP_001339958.1, XP_047304935.1, NP_079076.3, XP_054203914.1, XP_047304926.1

ZINC - World Drugs

NEK11_HUMAN

Guide to Pharmacology - Targets

2116

OpenTargets

ENSG00000114670

ENSEMBL

ENSG00000114670, ENSP00000426662, ENSP00000372857, ENSP00000423458, ENSP00000421851, ENST00000510688, ENSP00000425114, ENST00000508196, ENSP00000349389, ENST00000383366, ENST00000356918, ENST00000507910, ENST00000511262

ZINC - FDA approved

NEK11_HUMAN

ZINC - Substances

NEK11_HUMAN

ZINC - Biogenic

NEK11_HUMAN

ZINC target

Q8NG66

PRO

Q8NG66

GlyGen

Q8NG66

ZINC - Investigational

NEK11_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000114670-NEK11

GeneCards

NEK11

Pharos - Targets

Q8NG66

ZINC - Predictions - Purchasable

NEK11_HUMAN

HMDB Protein

HMDBP08768

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51955 NEK2	2	NEK2 [cytosol] (R-HSA-177329) NEK2 [endoplasmic reticulum lumen] (R-HSA-9931384)	0.619	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	2