Reactome | MBD3L2 binds MBD3 NuRD core complex

MBD3L2 binds MBD3 NuRD core complex

Stable Identifier

R-HSA-9940474

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

3/5

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MBD3L2 interacts with MBD3-containing NuRD complexes through the N-terminal region of MBD3 (Jin et al, 2005). MBD3L2 and homolog MBD3L1 are MBD2- and MBD3-related proteins that may modulate the repression activity of the NuRD complex (Jiang et al, 2002; Jiang et al, 2004l; Jin et al, 2005). MBD3L2 is more widely expressed and interacts with MBD3 through N-terminal regions in both proteins, but not with MBD2, as assessed by GST pulldowns in AD293 cells (Jin et al, 2005). MBD3L2 interacts with MBD3 through a region on MBD3 that partially overlaps with the MBD3-MBD2 interaction surface, suggesting a possible competitive binding model between MBD3L2 and MBD2 (Jin et al, 2005). This competition may play a role in displacing NuRD complexes from the DNA (Jin et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15701600	MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing Jin, SG, Jiang, CL, Rauch, T, Li, H, Pfeifer, GP	J Biol Chem	2005
15456747	MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex Jiang, CL, Jin, SG, Pfeifer, GP	J Biol Chem	2004
12504854	MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor Jiang, CL, Jin, SG, Lee, DH, Lan, ZJ, Xu, X, O'Connor, TR, Szabó, PE, Mann, JR, Cooney, AJ, Pfeifer, GP	Genomics	2002