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Go!
NEXT homodimer [nucleoplasm]
Stable Identifier
R-HSA-9935998
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nuclear RNA decay (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
The NEXT complex and ZC3H18 bind CBCA:m7GpppN-RNA (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT homodimer [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
35688134
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex
Puno, MR
,
Lima, CD
Cell
2022
Participants
components
x 2
RBM7:ZCCHC8:SKIV2L2 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA (Homo sapiens)
as an input of
The NEXT complex and ZC3H18 bind CBCA:m7GpppN-RNA (Homo sapiens)
The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA (Homo sapiens)
as a component of
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
Inferred To
NEXT homodimer [nucleoplasm]
(Bos taurus)
NEXT homodimer [nucleoplasm]
(Caenorhabditis elegans)
NEXT homodimer [nucleoplasm]
(Canis familiaris)
NEXT homodimer [nucleoplasm]
(Danio rerio)
NEXT homodimer [nucleoplasm]
(Dictyostelium discoideum)
NEXT homodimer [nucleoplasm]
(Drosophila melanogaster)
NEXT homodimer [nucleoplasm]
(Gallus gallus)
NEXT homodimer [nucleoplasm]
(Mus musculus)
NEXT homodimer [nucleoplasm]
(Rattus norvegicus)
NEXT homodimer [nucleoplasm]
(Saccharomyces cerevisiae)
NEXT homodimer [nucleoplasm]
(Schizosaccharomyces pombe)
NEXT homodimer [nucleoplasm]
(Sus scrofa)
NEXT homodimer [nucleoplasm]
(Xenopus tropicalis)
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