Reactome | MIB2 [Golgi membrane]

MIB2 [Golgi membrane]

Stable Identifier

R-HSA-9931441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

E3 ubiquitin-protein ligase MIB2, Mind bomb homolog 2

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        MIB2-mediated K63-ubiquitination of CD274 (Homo sapiens)
        
        MIB2 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96AX9 MIB2

Gene Names

MIB2, SKD, ZZANK1

Chain

chain:1-955

Reference Genes

BioGPS Gene:142678 MIB2

COSMIC - genes:MIB2 MIB2

CTD Gene:142678 MIB2

dbSNP Gene:142678 MIB2

ENSEMBL:ENSG00000197530 MIB2

HGNC:30577 MIB2

KEGG:hsa:142678 MIB2

Monarch:142678 MIB2

NCBI Gene:142678 MIB2

OMIM:611141 MIB2

UCSC:Q96AX9 MIB2

Reference Transcript

Other Identifiers

142678

2316100

2316101

2316102

2316103

241541_PM_at

241541_at

4042283

4042284

4042285

4042286

4042287

4042389

4042391

4042394

4042395

4042397

4042398

4042399

4042400

4042401

4042410

4042412

4042413

4042416

4042420

4042423

A_14_P110651

A_33_P3214925

A_33_P3308903

GE484786

GO:0000151

GO:0003779

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0007219

GO:0008092

GO:0008270

GO:0010803

GO:0016567

GO:0016740

GO:0043123

GO:0046872

GO:0061630

GO:0140096

HMNXSV003020916

HMNXSV003042906

Hs.209424.0.A1_3p_at

Hs.209424.0.A1_3p_x_at

ILMN_1808107

ILMN_2282077

ILMN_2385178

TC01000046.hg

Other forms of this molecule

MIB2 [cytosol]

Inferred To

MIB2 [Golgi membrane] (Bos taurus)

MIB2 [Golgi membrane] (Canis familiaris)

MIB2 [Golgi membrane] (Gallus gallus)

MIB2 [Golgi membrane] (Mus musculus)

MIB2 [Golgi membrane] (Rattus norvegicus)

MIB2 [Golgi membrane] (Sus scrofa)

Cross References

RefSeq

NP_001164158.3, NP_001164160.1, XP_054190486.1, NP_001164159.2, NP_001164157.3, XP_054190488.1, XP_047302628.1, NP_543151.4, XP_011539039.2

OpenTargets

ENSG00000197530

ENSEMBL

ENSG00000197530, ENSP00000426128, ENSP00000348081, ENSP00000426103, ENSP00000428660, ENSP00000367980, ENSP00000367984, ENSP00000428264, ENST00000505820, ENST00000504599, ENST00000378708, ENST00000355826, ENST00000520777, ENST00000378712, ENST00000518681

HPA

ENSG00000197530-MIB2

GeneCards

MIB2

PRO

Q96AX9

Pharos - Targets

Q96AX9

Orphanet

MIB2

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13422 IKZF1	1	IKZF1 [nucleoplasm] (R-HSA-9944878)	0.527	2
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.499	2

Cite Us!