Heme assimilation

Stable Identifier
R-HSA-9927020
Type
Pathway
Species
Homo sapiens
Related Species
Escherichia coli
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Heme assimilation
Click the image above or here to open this pathway in the Pathway Browser
The ability to use iron derived from heme compounds represents an alternative iron uptake mechanism for enterobacteria growing in an iron-limited environment (Law et al., 1992; reviewed in Caza & Kronstadt, 2013). Extracellular serine proteases of SPATE type (EspC, Hbp) cleave host hemoglobin, releasing free heme, which is imported by TonB-dependent receptors; binding of heme to a binding protein in the periplasm then enables cytosolic import by the ABC transporter DppBCDF (reviewed in Wandersman & Delepelaire, 2012; Brewitz et al., 2016; Li et al., 2024).
Literature References
PubMed ID Title Journal Year
28012743 Structural and functional diversity of transient heme binding to bacterial proteins

Brewitz, HH, Hagelueken, G, Imhof, D

Biochim Biophys Acta Gen Subj 2017
39359680 Heme homeostasis and its regulation by hemoproteins in bacteria

Li, Y, Han, S, Gao, H

mLife 2024
1385631 The iron uptake mechanisms of enteropathogenic Escherichia coli: the use of haem and haemoglobin during growth in an iron-limited environment

Law, D, Wilkie, KM, Freeman, R, Gould, FK

J Med Microbiol 1992
22715905 Haemophore functions revisited

Wandersman, C, Delepelaire, P

Mol Microbiol 2012
24312900 Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans

Caza, M, Kronstad, JW

Front Cell Infect Microbiol 2013
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
iron acquisition from host (0044847)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-10-31)
Created
Stephan, R  (2024-11-04)
Cite Us!