MITF-M-dependent CDC25B gene expression

Stable Identifier
R-HSA-9926524
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent CDC25B gene expression
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CDC25B is a tyrosine protein phosphatase that dephosphorylates CDK1, stimulating its kinase activity and thereby promotes G2/M transition (Timofeev et al, 2010). By ChIP and RNAseq analysis, CDC25B has been identified as a direct target of MITF-M-dependent regulation (Strub et al, 2011).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
20360007 Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition

Timofeev, O, Cizmecioglu, O, Settele, F, Kempf, T, Hoffmann, I

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:CDC25B gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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