MITF-M binds ZEB1 gene

Stable Identifier
R-HSA-9926484
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M binds ZEB1 gene
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MITF-M binds to a cognate element in the ZEB1 locus to repress its expression as assessed by CUT-and-RUN DNA binding analysis and ChIP-seq (Webster et al, 2014; Laurette et al, 2015; Dilshat et al, 2021). Consistent with this, expression levels of MITF and ZEB1 are inversely correlated in analysis of TCGA data, and ZEB1 expression is upregulated in tumors expressing low levels of MITF and in CRISPR-mediated knockout melanoma cell lines (Dilshat et al, 2021).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
24443471 Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

Webster, DE, Barajas, B, Bussat, RT, Yan, KJ, Neela, PH, Flockhart, RJ, Kovalski, J, Zehnder, A, Khavari, PA

Genome Res 2014
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Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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