MITF-M binds GXYLT2 gene

Stable Identifier
R-HSA-9926477
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M binds GXYLT2 gene
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MITF-M binds to the GXLYT2 gene to repress expression in melanoma cells as assessed by ChIP-seq, CRISPR and si/shRNA-mediated knockdown and CUT-and-RUN DNA binding analysis (Laurette et al, 2015; Webster et al, 2014; Dilshat et al, 2021). GXYLT2 encodes a glycosyltransferase that extends glycosylation groups of NOTCH proteins (Sethi et al, 2010). GXYLT2 has been implicated in the regulation of cell growth and migration in cancer through its impact on Notch signaling and may also play a role in epithelial-to-mesenchymal transition in gastric cancer (Cui et al, 2019; Song et al, 2023; Zhao and Cai, 2025), consistent with a role for MITF-M in regulating these processes (reviewed in Goding and Arnheiter, 2019; Rambow et al, 2019).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
19940119 Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats

Sethi, MK, Buettner, FF, Krylov, VB, Takeuchi, H, Nifantiev, NE, Haltiwanger, RS, Gerardy-Schahn, R, Bakker, H

J Biol Chem 2010
24443471 Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

Webster, DE, Barajas, B, Bussat, RT, Yan, KJ, Neela, PH, Flockhart, RJ, Kovalski, J, Zehnder, A, Khavari, PA

Genome Res 2014
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
37986328 Pan-cancer analysis of the prognostic significance and oncogenic role of GXYLT2

Song, YB, Bao, WG, Liu, DH, Wei, LQ, Yang, ST, Miao, XJ, Lin, CY, Li, HJ, Lan, D, He, HM

Medicine (Baltimore) 2023
31575676 Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

Rambow, F, Marine, JC, Goding, CR

Genes Dev 2019
39492929 A potential target of GXYLT2 affecting the prognosis of gastric cancer by enhancing the EMT process: A clinical retrospective study

Zhao, Y, Li, L, Cai, Z

Oncol Lett 2025
30716301 GXYLT2 accelerates cell growth and migration by regulating the Notch pathway in human cancer cells

Cui, Q, Xing, J, Gu, Y, Nan, X, Ma, W, Chen, Y, Zhao, H

Exp Cell Res 2019
Participants
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Output
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Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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