NS2B3 binds NFKBIA

Stable Identifier
R-HSA-9921168
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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NS2B3 binds NFKBIA
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DENV protease NS2B:NS3 (NS2B3) complex binds to NF-kappaB inhibitor alpha (NFKBIA, IKBA, MAD3, NFKBI) which is subsequently cleaved, resulting in NF-kB p65 and p50 nuclear translocation and activation of the extrinsic apoptotic pathway (Lin et al., 2014).
Literature References
PubMed ID Title Journal Year
24973451 Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development

Lin, JC, Lin, SC, Chen, WY, Yen, YT, Lai, CW, Tao, MH, Lin, YL, Miaw, SC, Wu-Hsieh, BA

J Immunol 2014
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-05)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-06)
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