Protein C coats dengue genomic +ssRNA

Stable Identifier
R-HSA-9920243
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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Protein C coats dengue genomic +ssRNA
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The capsid protein of dengue virus, known as Protein C, coats the genomic +ssRNA to form a spherical/globular ribonucleocapsid of low molecular weight (Kuhn et al. 2002; Boon et al., 2023; Mebus-Antunes et al., 2022; reviewed in Apte-Sengupta et al., 2014; Tan et al., 2020). There is differing evidence for the number of C molecules involved. Here we show 60 C molecules forming the capsid.
Literature References
PubMed ID Title Journal Year
37175867 Dengue Virus Capsid Protein Facilitates Genome Compaction and Packaging

Boon, PLS, Martins, AS, Lim, XN, Enguita, FJ, Santos, NC, Bond, PJ, Wan, Y, Martins, IC, Huber, RG

Int J Mol Sci 2023
25462445 Coupling of replication and assembly in flaviviruses

Apte-Sengupta, S, Sirohi, D, Kuhn, RJ

Curr Opin Virol 2014
35231063 The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles

Mebus-Antunes, NC, Ferreira, WS, Barbosa, GM, Neves-Martins, TC, Weissmuller, G, Almeida, FCL, Da Poian, AT

PLoS One 2022
32463839 Capsid protein is central to the birth of flavivirus particles

Tan, TY, Fibriansah, G, Lok, SM

PLoS Pathog 2020
11893341 Structure of dengue virus: implications for flavivirus organization, maturation, and fusion

Kuhn, RJ, Zhang, W, Rossmann, MG, Pletnev, SV, Corver, J, Lenches, E, Jones, CT, Mukhopadhyay, S, Chipman, PR, Strauss, EG, Baker, TS, Strauss, JH

Cell 2002
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
viral capsid assembly (0019069)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-10-07)
Reviewed
Mansur, DS  (2025-10-29)
Roque Ascenção, F  (2025-10-29)
Created
Orlic-Milacic, M  (2024-08-29)
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