NS5 is glutathionylated

Stable Identifier
R-HSA-9919982
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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NS5 is glutathionylated
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Dengue NS5 is S-glutathionylated at Cys665, Cys780 and Cys847 (Cys-3156, -3271, -3338 in the polyprotein) (Saisawang et al., 2018). The modification can occur through chemical mechanisms or be driven by enzymes such as glutathione S-transferase π (GSTπ) and glutaredoxin (Grx) (reviewed by Kukulage et al., 2022).
Literature References
PubMed ID Title Journal Year
29470500 Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities

Saisawang, C, Kuadkitkan, A, Auewarakul, P, Smith, DR, Ketterman, AJ

PLoS One 2018
36223700 Emerging chemistry and biology in protein glutathionylation

Kukulage, DSK, Matarage Don, NNJ, Ahn, YH

Curr Opin Chem Biol 2022
Participants
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Output
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as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-08-19)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-08-29)
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