NS2B3 cleaves prepro-C at the C-prM junction

Stable Identifier
R-HSA-9918876
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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NS2B3 cleaves prepro-C at the C-prM junction
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Dengue virus NS2B:NS3 (NS2B3) peptidase cleaves prepro-C at the C-prM junction (Shiryaev et al., 2007).
Literature References
PubMed ID Title Journal Year
17067286 Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses

Shiryaev, SA, Kozlov, IA, Ratnikov, BI, Smith, JW, Lebl, M, Strongin, AY

Biochem J 2007
Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of NS2B3 [cytosol]

Physical Entity
NS2B3 [cytosol] (Dengue virus type 2)
Activity
serine-type endopeptidase activity (GO:0004252)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-08-18)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-08-18)
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