Unknown peptidase cleaves NS1-NS2A

Stable Identifier
R-HSA-9918780
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Unknown peptidase cleaves NS1-NS2A
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An unknown endoplasmic reticulum (ER)-membrane-bound host peptidase cleaves the DENV-4 NS1-NS2A junction, producing NS1 and NS2A; this mechanism was supported by experiments using monkey CV-1 cells, human TK-143 cells, and in vitro assays with dog pancreas microsomes (Falgout et al., 1995; reviewed in Verhaegen & Vermeire, 2024). We are inferring the same process with DENV-2 proteins from these results.
Literature References
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Output
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Catalyst Activity

serine-type endopeptidase activity of unknown protease [endoplasmic reticulum membrane]

Physical Entity
unknown protease [endoplasmic reticulum membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-08-18)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2024-08-18)
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