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NS2A [endoplasmic reticulum membrane]
Stable Identifier
R-DVI-9918789
Type
Protein [EntityWithAccessionedSequence]
Species
Dengue virus type 2
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Dengue Virus Infection (Homo sapiens)
Dengue Virus Genome Translation and Replication (Homo sapiens)
Cap-dependent translation of DENV genomic RNA (Homo sapiens)
DENV circular genomic +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
Circularization of (+)-genomic RNA (Homo sapiens)
DENV +ssRNA with no secondary structures:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV circular genomic +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
Circularization of (-)-genomic RNA (Homo sapiens)
DENV -ssRNA with no secondary structures:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV circular genomic -ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV capped genome (+)-RNA dissociates from RC (Homo sapiens)
DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV genomic RNA binds Replication Complex (Homo sapiens)
DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
Maturation of DENV proteins (Homo sapiens)
Unknown peptidase cleaves NS1-NS2A (Homo sapiens)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS3 cleaves triphosphate moiety of genomic +ssRNA (Homo sapiens)
DENV nascent +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV pp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS3 melts (+)-RNA secondary structures (Homo sapiens)
DENV +ssRNA with no secondary structures:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS3 unwinds dsRNA secondary structures (Homo sapiens)
DENV -ssRNA genome replicate with secondary dsRNA structure:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV -ssRNA with no secondary structures:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA (Homo sapiens)
DENV m7G(5')ppp-+ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS5 acts as a cap N7 methyltransferase to methylate 5’ G pppA of DENV genomic +ssRNA (Homo sapiens)
DENV Gppp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV m7G(5')ppp-+ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS5 synthesizes minus strand genome (Homo sapiens)
DENV -ssRNA genome replicate with secondary dsRNA structure:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV circular genomic +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS5 synthesizes plus strand genome (Homo sapiens)
DENV circular genomic -ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV nascent +ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
NS5 transfers guanylyl onto DENV genomic 5'-ppRNA (Homo sapiens)
DENV Gppp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
DENV pp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
Nonstructural proteins form the replication complex (Homo sapiens)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
NS2A [endoplasmic reticulum membrane] (Dengue virus type 2)
External Reference Information
External Reference
UniProt:P29990 Unknown
Chain
chain:1-3391, chain:1-100, propeptide:101-114, chain:115-280, chain:115-205, chain:206-280, chain:281-775, chain:776-1127, chain:1128-1345, chain:1346-1475, chain:1476-2093, chain:2094-2220, peptide:2221-2243, chain:2244-2491, chain:2492-3391
Reference Genes
UCSC:P29990
Participates
as an output of
Unknown peptidase cleaves NS1-NS2A (Homo sapiens)
as an input of
Nonstructural proteins form the replication complex (Homo sapiens)
as a component of
Replication complex (RC) [endoplasmic reticulum membrane] (Dengue virus type 2)
Other forms of this molecule
N-glycan pr [exocytic vesicle]
C [lipid droplet]
N4GlycoAsn-prM [virion membrane]
pre-E [nuclear envelope]
N-glycan NS1 [clathrin-coated endocytic vesicle]
NS2B [nucleoplasm]
NS3 [mitochondrial matrix]
N-glycan NS1 [extracellular region]
2xN4GlycoAsn-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
N4GlycoAsn-prM [endoplasmic reticulum membrane]
N4GlycoAsn-prM [endoplasmic reticulum-Golgi intermediate compartment membrane]
N-glycan myristoyl-E [endoplasmic reticulum membrane]
K27polyUb-NS3 [nucleoplasm]
Fragment [cytosol]
C [nucleoplasm]
p-NS5 [endoplasmic reticulum membrane]
p-SGltCys-NS5 [endoplasmic reticulum membrane]
p-SGltCys-NS5 [nucleoplasm]
NS5 [nucleoplasm]
N-glycan NS1 [extracellular exosome]
N-glycan myristoyl-E [extracellular exosome]
N-glycan prM [extracellular exosome]
N-glycan NS1 [plasma membrane]
N-glycan myristoyl-E [plasma membrane]
N-glycan prM [plasma membrane]
K27polyUb-NS3 [endoplasmic reticulum membrane]
NS5 [endoplasmic reticulum membrane]
NS2B [endoplasmic reticulum membrane]
NS345 [endoplasmic reticulum membrane]
NS3 [endoplasmic reticulum membrane]
NS4AB [endoplasmic reticulum membrane]
pre-NS5 [endoplasmic reticulum membrane]
folded HyPro-Polyprotein [endoplasmic reticulum membrane]
C-prM-E-NS12A [endoplasmic reticulum membrane]
unfolded HyPro-Polyprotein [endoplasmic reticulum membrane]
Nascent polyprotein [endoplasmic reticulum membrane]
Nascent polyprotein [cytosol]
NS4A [endoplasmic reticulum membrane]
N-glycan NS1 [cytosol]
NS4B [endoplasmic reticulum membrane]
C [cytosol]
K48polyUb-N-glycan NS1 [cytosol]
prepro-NS4B [endoplasmic reticulum membrane]
Peptide 2K [cytosol]
NS2B [cytosol]
NS12A [endoplasmic reticulum membrane]
pre-NS1 [endoplasmic reticulum membrane]
prM-E-NS12A [endoplasmic reticulum membrane]
pre-E [endoplasmic reticulum membrane]
pre-prM [endoplasmic reticulum membrane]
prepro-C [cytosol]
N-glycan NS1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
M [virion membrane]
N-glycan myristoyl-E [virion membrane]
C [viral capsid]
Cross References
IntEnz
3.4.21.91
,
2.7.7.48
,
3.6.1.15
,
2.1.1.57
ZINC - Substances
POLG_DEN26
ZINC target
P29990
PRO
P29990
ZINC - Predictions - Purchasable
POLG_DEN26
PDB
6ZQU
,
6WY1
,
4O6B
,
6WER
,
7K93
,
2R69
HMDB Protein
HMDBP14413
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00974 BPT1
0.697
4
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