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PSMC4:PSMC5 [nucleoplasm]
Stable Identifier
R-HSA-9918349
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RPT3:RPT6
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Independent G1/S DNA Damage Checkpoint (Homo sapiens)
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Circadian clock (Homo sapiens)
Degradation of CRY and PER proteins (Homo sapiens)
Proteolysis of K48polyUb,p-S-CRY1,2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Participants
components
PSMC4 [nucleoplasm]
(Homo sapiens)
PSMC5 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
19S RP base [nucleoplasm] (Homo sapiens)
Inferred To
PSMC4:PSMC5 [nucleoplasm]
(Bos taurus)
PSMC4:PSMC5 [nucleoplasm]
(Caenorhabditis elegans)
PSMC4:PSMC5 [nucleoplasm]
(Canis familiaris)
PSMC4:PSMC5 [nucleoplasm]
(Danio rerio)
PSMC4:PSMC5 [nucleoplasm]
(Dictyostelium discoideum)
PSMC4:PSMC5 [nucleoplasm]
(Drosophila melanogaster)
PSMC4:PSMC5 [nucleoplasm]
(Gallus gallus)
PSMC4:PSMC5 [nucleoplasm]
(Mus musculus)
PSMC4:PSMC5 [nucleoplasm]
(Plasmodium falciparum)
PSMC4:PSMC5 [nucleoplasm]
(Rattus norvegicus)
PSMC4:PSMC5 [nucleoplasm]
(Sus scrofa)
PSMC4:PSMC5 [nucleoplasm]
(Xenopus tropicalis)
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