TEM-1 hydrolyzes penicillin G

Stable Identifier
R-HSA-9911520
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
cytosol
ReviewStatus
3/5
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TEM-1 hydrolyzes penicillin G
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Beta-lactamase TEM (TEM-1) is the most common beta-lactamase encoded on plasmids in Gram-negative bacteria. It effectively hydrolyses penicillins and many cephalosporins (Brown et al. 2009).
Literature References
PubMed ID Title Journal Year
19812041 Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis

Brown, NG, Shanker, S, Prasad, BV, Palzkill, T

J. Biol. Chem. 2009
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Catalyst Activity

beta-lactamase activity of TEM-1 [cytosol]

Physical Entity
TEM-1 [cytosol] (Escherichia coli)
Activity
beta-lactamase activity (GO:0008800)
Disease
Cross References
RHEA
Mondo
Authored
Stephan, R  (2019-02-19)
Created
Stephan, R  (2024-06-01)
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