AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region

Stable Identifier
R-HSA-9911516
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
periplasmic space, cell outer membrane, extracellular region
ReviewStatus
3/5
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AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region
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The tripartite efflux system acrA:acrB:tolC is the predominant efflux system in members of enterobacteria. It has a wide substrate profile, consisting of multiple different classes of antibiotics (chloramphenicols, tetracyclines, quinolones, macrolides, and β-lactams) and other xenobiotics like n-alkane solvents (Tsukagoshi & Aono, 2000). acrB is a transport protein of the Resistance-Nodulation-Cell Division (RND) superfamily which localizes to the plasma membrane. Together with the acrA bridge acrB is bound to the tolC trimer porin in the outer membrane, In the second reaction catalyzed by the tolC trimer, substrate diffuses to extracellular space (Zgurskaja & Nikaido 1999; reviewed by Alav et al., 2021).
Literature References
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Output
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as an event of
Catalyst Activity

porin activity of AcrA:AcrB:TolC [cell outer membrane]

Physical Entity
AcrA:AcrB:TolC [cell outer membrane] (Escherichia coli)
Activity
porin activity (GO:0015288)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-05-28)
Created
Stephan, R  (2024-06-01)
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