Maturation of the preholospermatoproteasome

Stable Identifier
R-HSA-9908780
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Maturation of the preholospermatoproteasome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on the analogy with the canonical 20S core particle (20S CP), it is assumed that, upon dimerization of two half-spermatoproteasomes to form the preholospermatoproteasome, the active site–bearing beta-subunits, PSMB5 (beta-5), PSMB6 (beta-1), and PSMB7 (beta-2), undergo autocatalytic cleavage of their propeptides, generating the mature catalytic sites and completing the spermatoproteasome 20S core particle (20S sCP) assembly (reviewed in Tomko and Hochstrasser 2013).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of Preholospermatoproteasome [cytosol]

Physical Entity
Preholospermatoproteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Inferred From
Maturation of the canonical 20S core particle (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-23)
Cite Us!