Reactome | Formation of the PA28-alpha-beta regulatory particle

Formation of the PA28-alpha-beta regulatory particle

Stable Identifier

R-HSA-9908686

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Formation of the PA28-alpha-beta regulatory particle

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PSME1 (PA28alpha) and PSME2 (PA28beta) form a heteroheptamer (PA28-alpha-beta heteroheptamer) that serves as an alternative regulatory particle (RP) in the immunoproteasome. The structure and stoichiometry of the human PA28-alpha-beta heteroheptamer, determined by cryogenic electron microscopy (cryo-EM) (Chen et al. 2021) correspond to the previously determined structure and stoichiometry of the mouse PA28-alpha-beta heteroheptamer (Huber and Groll 2017), so that the heteroheptamer is built of four PSME1 and three PSME2 subunits arranged consecutively, except for one PSME1 dimer (Chen et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
33531497	Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ Chen, J, Wang, Y, Xu, C, Chen, K, Zhao, Q, Wang, S, Yin, Y, Peng, C, Ding, Z, Cong, Y	Nat Commun	2021