Reactome | Metallochaperone inserts 2Cu2+ into MT-CO2

Metallochaperone inserts 2Cu2+ into MT-CO2

Stable Identifier

R-HSA-9865630

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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Metallochaperone inserts 2Cu2+ into MT-CO2

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A metallochaperone complex consisting of nine subunits (COA3, COA5, COX10, dimeric COX11, COX15, COX16, COX19, SCO1, SCO2) carries two copper cations from the outer side of the inner mitochondrial membrane, where they were delivered by the copper chaperone COX17, to the pre-assembled MT-CO2 subunit. These copper ions are frequently called CuA (Nývltová et al., 2022; reviewed in Ruiz et al., 2021).

Literature References

PubMed ID	Title	Journal	Year
25926683	Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase Bode, M, Woellhaf, MW, Bohnert, M, van der Laan, M, Sommer, F, Jung, M, Zimmermann, R, Schroda, M, Herrmann, JM	Mol Biol Cell	2015
34504870	Role of Copper on Mitochondrial Function and Metabolism Ruiz, LM, Libedinsky, A, Elorza, AA	Front Mol Biosci	2021
35750769	Coordination of metal center biogenesis in human cytochrome c oxidase Nývltová, E, Dietz, JV, Seravalli, J, Khalimonchuk, O, Barrientos, A	Nat Commun	2022