Reactome | ME1 tetramerizes

ME1 tetramerizes

Stable Identifier

R-HSA-9861631

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Unphosphorylated malic enzyme 1 (ME1) forms a dimer of dimers (Bukato et al., 1995). PGAM5-mediated dephosphorylation of ME1 at S336 leads to ME1 dimerization and activation, which is reversed by NEK1 kinase-mediated S336 phosphorylation (Zhu et al., 2020).

Literature References

PubMed ID	Title	Journal	Year
7757881	Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain Bukato, G, Kochan, Z, Swierczyński, J	Int J Biochem Cell Biol	1995
31735643	Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis Zhu, Y, Gu, L, Lin, X, Liu, C, Lu, B, Cui, K, Zhou, F, Zhao, Q, Prochownik, EV, Fan, C, Li, Y	Mol Cell	2020