MITF-M and CTNNB1-dependent CCND1 expression

Stable Identifier
R-HSA-9858645
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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MITF-M and CTNNB1-dependent CCND1 expression
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Expression of the G1/S cyclin CCND1 is regulated in melanoma cells by the binding of MITF and CTNNB1 to their cognate binding sites in the promoter (Strub et al, 2011; Genovese et al, 2013; reviewed in Goding and Arnheiter, 2019). CTNNB1-driven CCND1 expression is negatively regulated by the repressor protein HINT1 in complex with the co-repressors SIN3A and HDAC1 (Genovese et al, 2013). MITF- and CTNNB1-responsive expression of CCND1 contributes to the proliferative capacity of melanoma cells (reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
22647378 The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells

Sioletic, S, Sgambato, A, Cittadini, A, Rettino, A, Ghosh, P, Genovese, G, Li, H

Cell Cycle 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Homo sapiens)
Active Unit
TCF/LEF:CTNNB1 [nucleoplasm]
Regulator
MITF-M dimer:CCND1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-28)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-13)
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