MITF-M dimer binds the MIR211 promoter

Stable Identifier
R-HSA-9858288
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the MIR211 promoter
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The MIR211 gene encoding mircroRNA miR-211 lies in intron 6 of the MITF-M target gene TRPM1, and as such is a co-transcriptional target of MITF-M-mediated regulation (Hunter et al, 1998). miR-211 expression is restricted to the melanocyte lineage, and its expression is frequently downregulated during melanoma progression (Guar et al, 2007; Duncan et al, 1998; Duncan et al, 2001). Direct binding and activation of MITF-M to the TRPM1/miR-211 locus has been demonstrated by ChIP, EMSA and reporter gene assay (Miller et al, 2004; Miller et al, 2005; Strub et al, 2011).
MITF-M-dependent miR-211 expression may contribute to melanocyte development and progression of melanoma through regulation of targets such as POU3F2, SERPINC3, AP1S2, IGFBP5 and SOX11, among others, whose disruption affects invasive properties of cells (Margue et al, 2013; Boyle et al, 2011; Levy et al, 2010; De Luca et al, 2016; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
11208852 Melastatin expression and prognosis in cutaneous malignant melanoma

Kauffman, M, Deeds, J, Donovan, M, Sober, AJ, Duncan, LM, Cronin, FE, McCarthy, JJ

J Clin Oncol 2001
21109473 Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma

Scott, KL, Fletcher, AL, Song, JS, Li, S, Novina, CD, Yokoyama, S, Khaled, M, Turley, SJ, Fisher, DE, Levy, C, Garraway, LA, Iliopoulos, D, Pinner, S, Janas, MM, Chen, PH, Schubert, S, Granter, SR

Mol Cell 2010
14744763 Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma

Widlund, HR, Hershey, CL, Fisher, DE, Rowan, S, Du, J, Miller, AJ

Cancer Res 2004
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
21435193 Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor

Sturm, RA, Hacker, E, Boyle, GM, Dutton-Regester, K, Stark, MS, Bonazzi, VF, Cook, AL, Woods, SL, Aoude, LG, Hayward, NK

Pigment Cell Melanoma Res 2011
15507434 Sumoylation of MITF and its related family members TFE3 and TFEB

Davis, IJ, Razin, E, Fisher, DE, Levy, C, Miller, AJ

J. Biol. Chem. 2005
9537257 Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis

Deeds, J, Shyjan, AW, Hunter, J, Shao, J, Duncan, LM, Holmgren, LM, Tepper, RI, Woolf, EA

Cancer Res 1998
9806836 Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)

Moore, KJ, Shyjan, AW, Nagle, DL, Hunter, JJ, Smutko, JS, Shao, J, Holmgren, LM, Woolf, EA, Dussault, BJ

Genomics 1998
26599548 miR-211 and MITF modulation by Bcl-2 protein in melanoma cells

Trisciuoglio, D, Pelosi, A, Del Bufalo, D, Di Martile, M, Candiloro, A, Desideri, M, Farini, V, Bellei, B, Regazzo, G, Tupone, MG, De Luca, T, Rizzo, MG, D'Aguanno, S

Mol Carcinog 2016
24039954 New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion

Philippidou, D, Behrmann, I, Margue, C, Kreis, S, Schmitt, M, Reinsbach, SE

PLoS One 2013
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Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-10)
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