AXL3 binds MITF promoter

Stable Identifier
R-HSA-9858238
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AXL3 binds MITF promoter
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Based on studies in African striped mouse, house mouse and chipmunk, ALX3 binds to conserved elements in the MITF promoter to repress transcription (Mallarino et al, 2016). ALX3 (aristaless-like homeobox 3) is a homeodomain protein that is expressed in neural crest derived mesenchyme and acts as a transcriptional regulator (ten Berge 1998; Perez-Villamil et al, 2004). Human and mouse ALX3 share ~90% identity and the three identified binding sites in the MITF promoter are conserved (Mallarino et al, 2016). Although in some cases ALX3 has been shown to bind DNA as a dimer, dimerization does not appear to be absolutely required and the DNA binding properties of ALX3 are impacted by interaction with other nuclear proteins and by the particular cellular environment (Perez-Villamil et al, 2004). The precise role of ALX3 in the regulation of melanocyte development and melanoma progression are not yet known.
Literature References
PubMed ID Title Journal Year
27806375 Developmental mechanisms of stripe patterns in rodents

Hoekstra, HE, Henegar, C, Barsh, GS, Mallarino, R, Manceau, M, Beronja, S, Vallejo, M, Mirasierra, M, Schradin, C

Nature 2016
15226305 The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation

Pérez-Villamil, B, Vallejo, M, Mirasierra, M

J Biol Chem 2004
9676189 Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm

Meijlink, F, ten Berge, D, Brouwer, A, el Bahi, S, Robert, B, Guénet, JL

Dev Biol 1998
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Alx3 binds the Mitf gene (Mus musculus)
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-10)
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