MITF-M dimer binds SIRT1 promoter

Stable Identifier
R-HSA-9854920
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds SIRT1 promoter
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MITF-M binds to the promoter of the histone deacetylase gene SIRT1 as assessed by ChIP (Strub et al, 2011). Consistent with this, knockdown of MITF-M by siRNA reduces the levels of SIRT1 mRNA and protein expression in melanoma cell lines and patient biopsy samples, concurrent with a reduction in the levels of deacetylation of known SIRT1 targets such as TP53 (Ohanna et al, 2014).
MITF-M-dependent SIRT1 expression contributes to proliferation and suppression of senescence in melanoma cells (Ohanna et al, 2014; reviewed in Goding and Arnheiter, 2019). SIRT1 expression may also contribute to metabolic reprogramming through deacetylation of targets such as PPARGC1A and CBP/p300 (Bosch-Presegue and Vaquero, 2011; Canto et al, 2009; Bouras et al, 2005)
Literature References
PubMed ID Title Journal Year
24742694 SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells

Ohanna, M, Bonet, C, Bille, K, Allegra, M, Davidson, I, Bahadoran, P, Lacour, JP, Ballotti, R, Bertolotto, C

Oncotarget 2014
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
21941620 The dual role of sirtuins in cancer

Bosch-Presegué, L, Vaquero, A

Genes Cancer 2011
15632193 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

Bouras, T, Fu, M, Sauve, AA, Wang, F, Quong, AA, Perkins, ND, Hay, RT, Gu, W, Pestell, RG

J Biol Chem 2005
19262508 AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C, Gerhart-Hines, Z, Feige, JN, Lagouge, M, Noriega, L, Milne, JC, Elliott, PJ, Puigserver, P, Auwerx, J

Nature 2009
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Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-11-28)
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