miR-21 RISC binds DNMT1 mRNA

Stable Identifier
R-HSA-9851147
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-21 RISC binds DNMT1 mRNA
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Translation of DNMT1 mRNA is negatively regulated by miR-21 (Zhang et al, 2011). In the context of NPM1-ALK signaling in ALCL, DNMT1 represses IL2RG gene expression by methylating the IL2RG promoter. STAT3 contributes to IL2RG repression both by faciliating the recruitment of repressors SIN3A and DNMT1 to the promoter, and by directly repressing miR-21 expression (Zhang et al, 2011; Gambi et al, 2019; reviewed in Fuchs et al, 2019).
Literature References
PubMed ID Title Journal Year
21715655 IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Wasik, M, Liu, X, Zhang, Q, Kantekure, K, Wang, HY, Bhutani, G

Proc. Natl. Acad. Sci. U.S.A. 2011
30692217 The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3

Verma, A, Inghirami, G, Gambi, G, Wang, R, Elemento, O, Basso, V, Di Simone, E, Mondino, A, Ponzoni, M, Icardi, L, Ricci, L

Cancer Res. 2019
31052302 Non-Coding RNA Networks in ALK-Positive Anaplastic-Large Cell Lymphoma

Fuchs, S, Naderi, J, Meggetto, F

Int J Mol Sci 2019
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Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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