STAT3-dependent MIR-21 gene expression

Stable Identifier
R-HSA-9851139
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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STAT3-dependent MIR-21 gene expression
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Expression of MIR21 is repressed by STAT3 binding to its promoter. STAT2-dependent repression of miR-21 in turn leads to upregulation of DNMT1, a miR-21 target. Downstream of NPM1-ALK, DNMT1 contributes to repression of IL2RG gene expression by methylating the IL2RG promoter (Zhang et al, 2011).
Literature References
PubMed ID Title Journal Year
21715655 IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Wasik, M, Liu, X, Zhang, Q, Kantekure, K, Wang, HY, Bhutani, G

Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MIR21 gene:AcK685-pY705,p-S727 STAT3 dimer [nucleoplasm] (Homo sapiens)
Active Unit
AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm]
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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