STAT3-dependent DNMT1 gene expression

Stable Identifier
R-HSA-9851137
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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STAT3-dependent DNMT1 gene expression
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STAT3 contributes to DNMT1 expression in NPM1-ALK cells both through direct activation at the transcriptional level and by downregulating expression of miR-21, a negative regulator of DNMT1 mRNA translation (Zhang et al, 2006; Zhang et al, 2011; Ambrogio et al, 2009).
Literature References
PubMed ID Title Journal Year
19887607 NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells

Chiarle, R, di Celle, PF, Ambrogio, C, Tondat, F, Martinengo, C, Inghirami, G, Riera, L, Voena, C

Cancer Res 2009
21715655 IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Wasik, M, Liu, X, Zhang, Q, Kantekure, K, Wang, HY, Bhutani, G

Proc. Natl. Acad. Sci. U.S.A. 2011
16861352 STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

Wasik, MA, Zhang, Q, Wang, HY, Odum, N, Woetmann, A, Raghunath, PN

Blood 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
AcK685-p-Y705, S727-STAT3 dimer:DNMT1 gene [nucleoplasm] (Homo sapiens)
Active Unit
AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm]
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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