NPM1-ALK- and TYK2-dependent MCL1 gene expression

Stable Identifier
R-HSA-9851112
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NPM1-ALK- and TYK2-dependent MCL1 gene expression
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MCL1 is a pro-survival member of the BCL2 family. MCL1 is upregulated in ALCL ALK+ lines in a manner that depends on active TYK2 protein (Prutsch et al, 2019). Stimulation of MCL1 expression may depend on phosphorylated STAT1 or STAT3, but direct binding of the STAT proteins to the MCL1 promoter has not been demonstrated in this context (Prutsch et al, 2019; Epling-Burnette et al, 2001). MCL1 expression contributes to the survival of ALCL cells (Prutsch et al, 2019; Rassidakis et al, 2002).
Literature References
PubMed ID Title Journal Year
30131584 Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

Prutsch, N, Gurnhofer, E, Suske, T, Liang, HC, Schlederer, M, Roos, S, Wu, LC, Simonitsch-Klupp, I, Alvarez-Hernandez, A, Kornauth, C, Leone, DA, Svinka, J, Eferl, R, Limberger, T, Aufinger, A, Shirsath, N, Wolf, P, Hielscher, T, Sternberg, C, Aberger, F, Schmoellerl, J, Stoiber, D, Strobl, B, Jäger, U, Staber, PB, Grebien, F, Moriggl, R, Müller, M, Inghirami, GG, Sanda, T, Look, AT, Turner, SD, Kenner, L, Merkel, O

Leukemia 2019
12057933 Overexpression of Mcl-1 in anaplastic large cell lymphoma cell lines and tumors

Rassidakis, GZ, Lai, R, McDonnell, TJ, Cabanillas, F, Sarris, AH, Medeiros, LJ

Am J Pathol 2002
11390502 Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils

Epling-Burnette, PK, Zhong, B, Bai, F, Jiang, K, Bailey, RD, Garcia, R, Jove, R, Djeu, JY, Loughran, TP, Wei, S

J Immunol 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-Y1054,Y1055-TYK2 [cytosol] (Homo sapiens)
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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