NPM1-ALK and FOXM1-dependent CCNB1 gene expression

Stable Identifier
R-HSA-9851092
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPM1-ALK and FOXM1-dependent CCNB1 gene expression
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Expression of CCNB1, a known FOXM1 transcriptional target, is upregulated in NPM1-ALK+ ALCL cells in a NPM1-ALK and FOXM1-dependent manner (Haque et al, 2019; Leung et al, 2001). FOXM1 binds to a consensus sequence in the CCNB1 promoter as assessed by chromatin immunoprecipitation (ChIP), and knockdown of FOXM1 abrogates CCNB1 expression in NPM1-ALK+ cells. Expression of CCNB1 and other FOXM1 targets contributes to cell growth and colony formation in NPM1-ALK cell lines (Haque et al, 2019).
Literature References
PubMed ID Title Journal Year
11682060 Over-expression of FoxM1 stimulates cyclin B1 expression

Ching, JC, Tsang, AC, Leung, TW, Yao, KM, Tong, CS, Lin, SS, Leung, WY, Wong, GG, Gimlich, R

FEBS Lett 2001
31390744 NPM-ALK Is a Key Regulator of the Oncoprotein FOXM1 in ALK-Positive Anaplastic Large Cell Lymphoma

Wang, P, Haque, M, Turner, SD, Barger, CJ, Huang, YH, Chen, W, Almowaled, M, Karpf, AR, Lai, R, Li, J

Cancers (Basel) 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NPM1-ALK;NPM1:FOXM1 [nucleoplasm] (Homo sapiens)
Active Unit
FOXM1 [nucleoplasm]
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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