NPM1-ALK and FOXM1-dependent CCNB1 gene expression

Stable Identifier
R-HSA-9851092
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NPM1-ALK and FOXM1-dependent CCNB1 gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Expression of CCNB1, a known FOXM1 transcriptional target, is upregulated in NPM1-ALK+ ALCL cells in a NPM1-ALK and FOXM1-dependent manner (Haque et al, 2019; Leung et al, 2001). FOXM1 binds to a consensus sequence in the CCNB1 promoter as assessed by chromatin immunoprecipitation (ChIP), and knockdown of FOXM1 abrogates CCNB1 expression in NPM1-ALK+ cells. Expression of CCNB1 and other FOXM1 targets contributes to cell growth and colony formation in NPM1-ALK cell lines (Haque et al, 2019).
Literature References
PubMed ID Title Journal Year
11682060 Over-expression of FoxM1 stimulates cyclin B1 expression

Leung, TW, Lin, SS, Tsang, AC, Tong, CS, Ching, JC, Leung, WY, Gimlich, R, Wong, GG, Yao, KM

FEBS Lett 2001
31390744 NPM-ALK Is a Key Regulator of the Oncoprotein FOXM1 in ALK-Positive Anaplastic Large Cell Lymphoma

Haque, M, Li, J, Huang, YH, Almowaled, M, Barger, CJ, Karpf, AR, Wang, P, Chen, W, Turner, SD, Lai, R

Cancers (Basel) 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NPM1-ALK;NPM1:FOXM1 [nucleoplasm] (Homo sapiens)
Active Unit
FOXM1 [nucleoplasm]
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
Cite Us!