Lumicitabine binds RdRP on nucleocapsid

Stable Identifier
R-HSA-9845222
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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Lumicitabine binds RdRP on nucleocapsid
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Lumicitabine (ALS-8176) is an orally administered nucleoside analog targeting the RSV polymerase. Two phase 2 trials showed mixed safety and efficacy results in reducing viral load in patients (DeVincenzo et al., 2015; Oey et al., 2023).
Literature References
PubMed ID Title Journal Year
37467213 Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results

Oey, A, McClure, M, Symons, JA, Chanda, S, Fry, J, Smith, PF, Luciani, K, Fayon, M, Chokephaibulkit, K, Uppala, R, Bernatoniene, J, Furuno, K, Stanley, T, Huntjens, D, Witek, J

PLoS One 2023
26580997 Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

DeVincenzo, JP, McClure, MW, Symons, JA, Fathi, H, Westland, C, Chanda, S, Lambkin-Williams, R, Smith, P, Zhang, Q, Beigelman, L, Blatt, LM, Fry, J

N Engl J Med 2015
Participants
Input
Output
Participates
as an event of
Disease
Cross References
Mondo
Authored
Stephan, R  (2023-09-28)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-09-28)
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