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PPHLN1 [nucleoplasm]
Stable Identifier
R-HSA-9844032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
fullName evidence="11"Periphilin-1, PPHLN_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Homo sapiens)
HUSH complex binds LINE1 (L1) RNA (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
MPHOSPH8 of the HUSH complex bound to retroelement chromatin binds ZCCHC8 of the NEXT complex (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
NEXT complex:HUSH complex:L1HS:L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
PPHLN1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NEY8 PPHLN1
Gene Names
PPHLN1, HSPC206, HSPC232
Chain
chain:1-458
Reference Genes
BioGPS Gene:51535 PPHLN1
COSMIC (genes):PPHLN1 PPHLN1
CTD Gene:51535 PPHLN1
dbSNP Gene:51535 PPHLN1
ENSEMBL:ENSG00000134283 PPHLN1
HGNC:19369 PPHLN1
Monarch:51535 PPHLN1
NCBI Gene:51535 PPHLN1
OMIM:608150 PPHLN1
UCSC:Q8NEY8 PPHLN1
Reference Transcript
RefSeq:NM_001143788.1 PPHLN1
RefSeq:NM_201515.1 PPHLN1
RefSeq:NM_016488.6 PPHLN1
RefSeq:NM_201440.1 PPHLN1
RefSeq:NM_201439.1 PPHLN1
RefSeq:NM_201438.1 PPHLN1
RefSeq:NM_001143787.1 PPHLN1
Other Identifiers
11728759_a_at
11729805_a_at
11734523_x_at
11735835_a_at
11735836_x_at
11739278_x_at
11752851_a_at
11752852_x_at
11762138_at
1555350_PM_at
1555350_at
1555351_PM_s_at
1555351_s_at
225073_PM_at
225073_at
227025_PM_at
227025_at
234459_3p_at
234459_PM_at
234459_at
3412009
3412016
3412017
3412022
3412023
3412024
3412025
3412026
3412027
3412028
3412029
3412030
3412031
3412035
3412036
3412037
3412039
3412040
3412041
3412042
3412043
3412044
3412046
3412047
3412057
3412058
3412059
3412060
3412061
3412062
3412063
3412064
3412065
3412066
3412067
3412068
3412069
3412070
3412091
3412092
3412103
43918_at
49017_at
51535
52493_at
7954940
A_14_P109481
A_14_P115994
A_14_P122247
A_14_P124809
A_14_P139565
A_23_P128436
A_24_P222454
A_32_P357301
A_33_P3368610
GE61389
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0005829
GO:0006325
GO:0006355
GO:0031424
GO:0043226
GO:0045814
GO:0045892
GO:0090309
GO:0097355
HMNXSV003004315
HMNXSV003026611
HMNXSV003052697
Hs.24853.0.A1_3p_at
Hs.281428.0.S1_3p_at
Hs.281428.1.S1_3p_at
Hs2.281428.3.S1_3p_at
Hs2.281428.3.S1_3p_s_at
ILMN_1706593
ILMN_1791093
ILMN_1805788
ILMN_2322842
PH_hs_0032924
Participates
as a component of
HUSH complex [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of PPHLN1 [nucleoplasm]
(Danio rerio)
PPHLN1 [nucleoplasm]
(Bos taurus)
PPHLN1 [nucleoplasm]
(Canis familiaris)
PPHLN1 [nucleoplasm]
(Gallus gallus)
PPHLN1 [nucleoplasm]
(Sus scrofa)
Pphln1 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000390681
,
ENSP00000378947
,
ENSP00000393965
,
ENSP00000378935
,
ENST00000358314
,
ENST00000395568
,
ENST00000449194
,
ENSP00000477681
,
ENST00000395580
,
ENSP00000478872
,
ENST00000613154
,
ENSP00000351066
,
ENST00000619544
,
ENSP00000479913
,
ENST00000432191
,
ENST00000552761
,
ENSP00000449331
,
ENST00000610488
OpenTargets
ENSG00000134283
HPA
ENSG00000134283-PPHLN1
PRO
Q8NEY8
Pharos - Targets
Q8NEY8
PDB
6SWG
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.483
2
UniProt:Q9Y6H5 SNCAIP
3
PolyUb-SNCAIP [cytosol]
(R-HSA-5667104)
K63Ub-SNCAIP [cytosol]
(R-HSA-5667114)
SNCAIP [cytosol]
(R-HSA-5333629)
0.463
2
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