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ALKAL2:(ALKAL1) [extracellular region]
Stable Identifier
R-HSA-9842597
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
ALK autophosphorylation (Homo sapiens)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALK binds ALKAL ligand (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALK-stimulated MYCN gene expression (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK binds FRS2 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK binds JAK3 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK binds PLCG1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK binds SHC1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK binds SRC (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK dimer binds IRS1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK phosphorylates FRS2 (Homo sapiens)
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:p-6Y FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK phosphorylates IRS1 (Homo sapiens)
Active ALK:IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:pY-IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK phosphorylates JAK3 (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:p-Y980 JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK phosphorylates PLCG1 (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK phosphorylates SHC1 (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:p-3Y SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK phosphorylates SRC (Homo sapiens)
Active ALK:SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:p-Y419 SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK recruits PI3K (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Liganded-ALK dimer binds type I ALK-binding TKIs (Homo sapiens)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
PTPN6 dephosphorylates JAK3 (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Active ALK:p-Y980 JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
STAT3 is phosphorylated downstream of active ALK (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
Participants
members
ALKAL2 dimer [extracellular region]
(Homo sapiens)
candidates
ALKAL1 [extracellular region]
(Homo sapiens)
Participates
as a component of
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
as an input of
ALK binds ALKAL ligand (Homo sapiens)
Inferred To
ALKAL2 dimer [extracellular region]
(Bos taurus)
ALKAL2 dimer [extracellular region]
(Gallus gallus)
ALKAL2:(ALKAL1) [extracellular region]
(Canis familiaris)
ALKAL2:(ALKAL1) [extracellular region]
(Danio rerio)
ALKAL2:(ALKAL1) [extracellular region]
(Mus musculus)
ALKAL2:(ALKAL1) [extracellular region]
(Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region]
(Sus scrofa)
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